Systematic literature review to identify prognostic factors of efficacy and safety outcomes of chimeric antigen receptor T-Cell therapies in diffuse large B-Cell lymphoma

Author(s)

Julia K Schleifenbaum, Jan-Michel Heger, Jonas Jost, Umberto Rosato, Sybille Riou, Peter Borchmann, Stefan Walzer, Jörg Mahlich

Abstract

PURPOSE: To identify and summarize clinical factors influencing the efficacy and safety outcomes of CAR-T cell therapies in patients with diffuse large B-cell lymphoma (DLBCL) through a systematic literature review.

METHODS: We performed a systematic literature review to identify factors impacting the efficacy and safety of CAR-T therapies in DLBCL. Articles were searched in PubMed, Cochrane, and EMBASE databases. Key outcomes, including progression-free survival (PFS), overall survival (OS), complete response rate (CRR), objective response rate (ORR), duration of response (DoR), best overall response (BOR), and safety measures (e.g., Immune Effector Cell-Associated Neurotoxicity Syndrome [ICANS], and Cytokine Release Syndrome [CRS]), were extracted according to PRISMA guidelines. A total of 712 articles were identified, with 185 selected for full-text screening. Ultimately, 79 articles met inclusion criteria. Exclusions were primarily due to the absence of relevant outcome data or publication type.

RESULTS: This review highlights several factors that may influence the efficacy and safety of CAR-T therapies in DLBCL, including Eastern Cooperative Oncology Group Performance Status (ECOG PS), International Prognostic Index (IPI) score, disease histology, Ann Arbor disease stage, and elevated LDH levels.

CONCLUSION: The findings of this review can assist clinicians in refining treatment strategies and improving patient outcomes in DLBCL by incorporating these key influencing factors.

Organisation(s)

Department of Economics

External organisation(s)

Universität zu Köln, MArS Market Access & Pricing Strategy GmbH, Miltenyi Biomedicine, Friedrich-Ebert-Straße 68, 51429, Bergisch Gladbach, Germany., Hochschule Ravensburg-Weingarten, Heinrich-Heine-Universität Düsseldorf

Journal

Journal of Cancer Research and Clinical Oncology

Volume

151

Pages

203

ISSN

0171-5216

DOI

https://doi.org/10.1007/s00432-025-06249-z

Publication date

07-2025

Peer reviewed

Yes

Austrian Fields of Science 2012

303010 Health economics

Keywords

ASJC Scopus subject areas

Oncology, Cancer Research

Portal url

https://ucrisportal.univie.ac.at/en/publications/8a10db0a-2ed1-4dd8-a579-dc0dbdb119df