Survival outcomes of patients newly diagnosed with diffuse large B-cell lymphoma

Peter Borchmann, Jan-Michel Heger, Jörg Mahlich, Michael S Papadimitrious, Sybille Riou, Barbara Werner

PURPOSE: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma with increasing incidence. Although the burden of disease is high, only limited current real-world data on survival analysis, especially survival time, of German patients with DLBCL are available. This retrospective claims-based analysis was conducted to describe real-world survival evidence and treatment patterns of patients with DLBCL in Germany.

METHODS: Using a large claims database of the German statutory health insurance with 6.7 million enrollees, we identified patients between 2010 and 2019 who were newly diagnosed with DLBCL (index date) and had no other cancer co-morbidity. Overall survival (OS) from index date and from the end of each treatment line was plotted by means of the Kaplan-Meier estimator, both for the overall cohort and stratified by treatment regimen. Treatment lines were identified based on a predefined set of medications categorized by established DLBCL treatment recommendations.

RESULTS: 2495 incident DLBCL patients were eligible for the study. After index date, 1991 patients started a first-line, 868 a second-line, and 354 a third-line therapy. In first line, 79.5% of patients received a Rituximab-based therapy. 5.0% of the of the 2495 patients received a stem cell transplantation. Overall, median OS after index was 96.0 months.

CONCLUSION: DLBCL-associated mortality is still high, especially in relapsed patients and in the elderly. Therefore, there is a high medical need for new effective treatments that can improve survival outcomes in DLBCL patients.

External organisation(s)
Universität zu Köln, Miltenyi Biomedicine, Friedrich-Ebert-Straße 68, 51429, Bergisch Gladbach, Germany., Heinrich-Heine-Universität Düsseldorf, Team Gesundheit
Journal of Cancer Research and Clinical Oncology
No. of pages
Publication date
Peer reviewed
Austrian Fields of Science 2012
302055 Oncology
ASJC Scopus subject areas
Oncology, Cancer Research
Sustainable Development Goals
SDG 3 - Good Health and Well-being
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