Survival outcomes of patients with diffuse large B-cell lymphoma undergoing autologous stem cell transplantation in Germany
- Author(s)
- Jan-Michel Heger, Peter Borchmann, Sybille Riou, Barbara Werner, Michael S Papadimitrious, Jörg Mahlich
- Abstract
BACKGROUND: Limited real-world evidence is available for patients with diffuse large B-cell lymphoma (DLBCL) who received an autologous stem cell transplantation (ASCT) in Germany.
OBJECTIVES: This study aims to describe the real-world survival outcomes of patients with DLBCL who received ASCT in Germany after diagnosis.
DESIGN: This study is a retrospective database analysis covering the period between 2010 and 2019.
METHODS: Unadjusted overall survival (OS) was plotted using the Kaplan-Meier estimator for the overall population and stratified by relapse status. A Cox regression was run to identify factors that influence OS.
RESULTS: A total of 112 patients received an ASCT, with the average time from first-line treatment to ASCT being 11.7 months. The median OS estimated by Kaplan-Meier was 83.4 months for the entire cohort. The only variable that significantly reduced the OS was the presence of subsequent treatment after ASCT in a time-dependent model.
CONCLUSION: OS after ASCT for DLBCL patients in Germany is higher than previously reported and may still be considered a valid option for carefully selected patients with relapsed/refractory DLBCL.
- Organisation(s)
- Department of Economics
- External organisation(s)
- Universität zu Köln, Miltenyi Biomedicine, Friedrich-Ebert-Straße 68, 51429, Bergisch Gladbach, Germany., Team Gesundheit Gesellschaft für Gesunheitsmanagement mbH, Heinrich-Heine-Universität Düsseldorf
- Journal
- Frontiers in Oncology
- Volume
- 14
- Pages
- 1432310
- ISSN
- 2234-943X
- DOI
- https://doi.org/10.3389/fonc.2024.1432310
- Publication date
- 2024
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 303040 Health services research
- Keywords
- ASJC Scopus subject areas
- Oncology, Cancer Research
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/survival-outcomes-of-patients-with-diffuse-large-bcell-lymphoma-undergoing-autologous-stem-cell-transplantation-in-germany(d3170519-65a7-447b-8cc2-d46ebed25635).html